Most Highly Expressed Protein-Coding Genes Have a Single Dominant Isoform
نویسندگان
چکیده
منابع مشابه
Capturing protein-coding genes across highly divergent species.
DNA hybridization capture combined with next generation sequencing can be used to determine the sequences of hundreds of target genes across hundreds of individuals in a single experiment. However, the approach has thus far only been successfully applied to capture targets that are highly similar in sequence to the bait molecules. Here we introduce modifications that extend the reach of the met...
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Many different selective effects on DNA and proteins infl uence the frequency of codons and amino acids in coding sequences. Selection is often stronger on highly expressed genes. Hence, by comparing highand low-expression genes it is possible to distinguish the factors that are selected by evolution. It has been proposed that highly expressed genes should (i) preferentially use codons matching...
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clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): February 29, 2012 www.sciencemag.org (this infomation is current as of The following resources related to this article are ava...
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PURPOSE Monomeric IgE molecules, when bound to the high-affinity receptor, exhibit a vast heterogeneity in their ability to induce survival promotion and cytokine production in mast cells. At one end of this spectrum, highly cytokinergic (HC) IgEs can induce potent survival promotion, degranulation, cytokine production, migration, etc., whereas at the other end, poorly cytokinergic (PC) IgEs ca...
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ژورنال
عنوان ژورنال: Journal of Proteome Research
سال: 2015
ISSN: 1535-3893,1535-3907
DOI: 10.1021/pr501286b